Isoenzymes of liver alkaline phosphatase in serum of patients with hepatobiliary disorders.
نویسندگان
چکیده
The isoenzymesof alkalinephosphatase(ALP; EC 3.1.3.1) present in the .sera of 116 patients with hepatobiliary disease were studied by electrophoresis on cellulose acetate. Individual liver isoenzyme bandswere identified an quantitated by densitometnc scanning. The occurrence and magnitude of increase of the isoenzyme bands of liver ALP (a2 alone or a1 and cx2) are related to diagnosis. Of the cases studied, 30% showed only the a2 band of liver ALP. A couplet of liver isoenzyme bands (ai and a2) was seen in 70% of the cases studied. The isolated a2 band occurred in 26 of 36 patients with viral hepatitis and in two patients with hepatic infarction. Most patients with other liver diseases showed the ai and a2 couplet. The serum pattern of liver ALP is relatedto totalALP, age, ABO blood group, and serum bilirubin concentration. The ai band is markedly increased in patients with granulomatous hepatitis and carcinoma metastatic to the liver. The findings are related to previous work, and their implications are discussed.
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 19 10 شماره
صفحات -
تاریخ انتشار 1973